In vivo demonstration of an active tumor pretargeting approach with peptide nucleic acid bioconjugates as complementary system

Department of Chemistry, University of Zu Zurich, Switzerland. E-mail: gilles.ga gassergroup.com; Tel: +41 44 635 46 30 Helmholtz-Zentrum Dresden – Rossendorf, Research, Bautzner Landstraße 400, [email protected]; Web: http://www.hzdr.d 3091 Lehrstuhl für Anorganische Chemie I – Bioa und Biochemie, Ruhr-Universität Bochum, U Germany † Electronic supplementary information PNAs used this study (Fig [Tc](Tc-Dpa)-(Cys-PEG10kDa)-PNA (Fig. three complementary 17-mer PNA sys different PNAs (Fig. S16), radio HPLC of t (original), in rat arterial blood plasma (Fi PNAs in Wistar rats (%ID mean radiolabeled PNAs in Wistar rats (SUV comparison of the biodistribution of [ and mouse (Fig. S18). See DOI: 10.1039/c5 ‡ These authors have contributed equally § Current address: Department of On University Avenue, Edmonton, Alberta, T6 Cite this: Chem. Sci., 2015, 6, 5601